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Adriamycin (Doxorubicin) | DNA intercalator

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Catalog #:

Product Description

Adriamycin (Doxorubicin) is an intravenous, anthracycline-based antibiotic and antineoplastic agent derived from Streptomyces bacterium. Adriamycin enters cancer cell DNA and inhibits cell replication by arresting protein synthesis.

In HK-2 cells, adriamycin decreases cell viability in a dose-dependent manner and induces an increase in cells in the sub G1 and G2/M phases. It also increases secretion of TNFa, decreases expression of phosphorylated PKA and Bcl-2, and increases phosphoryled signal transducer and activator of transcription 3, phospho-ERK,and ATF3. [1]

Due to adriamycin's route of administration and cytotoxic effects, extensive research has been conducted in the area of assisted delivery of the chemotherapeutic (liposome [2], prodrug [3], polymer, gold-particles, etc.)

Technical information:

Chemical Formula:   C27H29NO11.HCl
CAS #:   25316-40-9
Molecular Weight:   579.98
Purity:   > 98%
Appearance:   Red Orange
Chemical Name:   (8S,10S)-10-((2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyl-tetrahydro-2H-pyran-2-yloxy)-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-7,8,9,10-tetrahydrotetracene-5,12-dione hydrochloride
Solubility:   Up to 100mM in DMSO
Synonyms:   Adriablastin, Adriblastin, Adriblastina, Adriamycin, Doxorubicine, Rubex, Doxorubicinum, Doxorubicina, Doxil

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Park et al., Doxorubicin induces cytotoxicity through upregulation of pERK-dependent ATF3. PLoSONE, 2012, 7(9), e44990. Pubmed ID: 23028726
2. Macmillan and Cancer Backup factsheet
3. Albright et al., Matrix metalloproteinase-activated doxorubicin prodrugs inhibit HT1080 xenograft growth better than doxorubicin with less toxicity. Mol. Cancer Ther. 2005, 4, 751-760. Pubmed ID: 15897239

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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