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Cyclophosphamide | DNA alkylating agent

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Catalog #:

Product Description

Cyclophosphamide, an immunosuppressant administered either orally or intravenously, is an antineoplastic prodrug metabolized by P450 enzymes to phosphoramide mustard and acrolein which in turn alkylate DNA and proteins, respectively [1]. It is widely used in the treatment of chronic lymphocytic leukemia, lymphomas, and soft tissue and osteogenic sarcomas. [2]

Cyclophosphamide was shown to induce apoptosis in wt 9L gliosarcoma cells that did not express Bcl-2. Bcl-2 diminishes cyclophosphamide's cytotoxic activity, but not cytostatic activity. [1]

Technical information:

Chemical Formula:   C7H15Cl2N2O2P.H2O
CAS #:   6055-19-2
Molecular Weight:   261.09
Purity:   > 99%
Appearance:   White Crystalline
Chemical Name:   (RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide
Solubility:   Up to 100 mM in DMSO
Synonyms:   Cyclophosphamide, Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


1. Schwartz et al., Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol. Pharmcol. 2001, 60(6), 1268-1279. Pubmed ID: 11723234
2. Cyclophosphamide IARC monograph

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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