Reversine is a 2,6-disubstituted purine derivative as a potent, selective A3 adenosine receptor antagonist. Reversine could induce differentiated myogenic-linage committed cells to become multipotent mesenchymal progenitor cells. Cultured myoblasts treated for four days with 5 µM reversine were dedifferentiated into confluent stem cell progenitors, that could then be induced by osteogenic or adipogenic medium to re-differentiate into bone or adipose precursors, respectively.
Technical information:
| Chemical Formula: | C21H27N7O | |
| CAS #: | 656820-32-5 | |
| Molecular Weight: | 393.45 | |
| Purity: | >98% | |
| Appearance: | White solid | |
| Chemical Name: | N6-cyclohexyl-N2-(4-morpholinophenyl)-1H-purine-2,6-diamine | |
| Solubility: | Up to 50 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Chen S, Zhang Q, Wu X, Schultz PG, Ding S. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc.,(2004), 126(2):410–411. |
| 2. | Chen S, Takanashi S, Zhang Q, Xiong W, Zhu S, Peters EC, Ding S, Schultz PG. Reversine increases the plasticity of lineage-committed mammalian cells. Proc Natl Acad Sci U S A. (2007), 104(25):10482-7. |
| 3. | Perreira M, Jiang JK, Klutz AM, Gao ZG, Shainberg A, Lu C, Thomas CJ, Jacobson KA. "Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists. J Med Chem. (2005), 48(15):4910-8. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
