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TMC207 (Bedaquiline) | ATP synthase inhibitor

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Price:
$129.00
Catalog #:
C8207
Quantity:


Product Description

TMC207 (Bedaquiline) is a diarylquinoline-based inhibitor of bacterial ATP synthase at nanomolar concentrations. In vitro mycobacterial experiments show that TMC207 inhibits drug-sensitive and drug-resistant mycobacterial TB at an MIC range of 2 to 60 nM and an MIC50 of 30 ng/mL. Additionally TMC207 is broadly potent against many non-tuberculous mycobacteria, with MICs of 6 to 500 nM. (1)

Studies show that TMC207 is orally-available and efficacious on a once-daily administration for patients with pulmonary TB. No serious adverse events were observed. (2)


Technical information:

Chemical Formula:   C32H31BrN2O2
CAS #:   843663-66-1
Molecular Weight:   555.5
Purity:   > 98%
Appearance:   white
Chemical Name:   (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
Solubility:   Up to 2 mM in DMSO
Synonyms:   TMC207, TMC-207, Bedaquiline

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Matteelli et al., TMC207: the first compoudn of a new class of potent anti-tuberculosis drugs. Future Microbiol. 2010, 5(6), 849-858. Pubmed ID: 20521931
2. Rustomjee et al., Early Bactericidal Activity and Pharmacokinetics of the Diarylquinoline TMC207 in Treatment of Pulmonary Tuberculosis. Antimicrob. Agents Chemother. 2008, 52(8), 2831-2835. Pubmed ID: 18505852

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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