VX-680 (Tozasertib) is a small molecule Aurora kinase inhibitor (Aurora-A ~0.6nM, Aurora-B ~18nM, Aurora-C ~4.6nM). VX-680 inhibits cell cycle progression, induces apoptosis and blocks tumor growth in varieties of in vivo xenograft models, including leukemia, colon and pancreatic tumors.
Technical information:
| Chemical Formula: | C23H28N8OS | |
| CAS #: | 639089-54-6 | |
| Molecular Weight: | 464.59 | |
| Purity: | >98% | |
| Appearance: | Light yellow solid | |
| Chemical Name: | N-(4-((4-((5-methyl-1H-pyrazol-3-yl)amino)-6-(4-methylpiperazin-1-yl)pyrimidin-2-yl)thio)phenyl)cyclopropanecarboxamide | |
| Solubility: | Up to 100 mM in DMSO |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Elizabeth A Harrington, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nature Medicine 2004;10, 262 – 267. |
| 2. | Marumoto T, Zhang D, Saya H. Aurora-A - a guardian of poles. Nat Rev Cancer. 2005; 5(1):42-50. |
Other Information:
Product Specification (pdf)
MSDS (pdf)
