Cyclophosphamide, an immunosuppressant administered either orally or intravenously, is an antineoplastic prodrug metabolized by P450 enzymes to phosphoramide mustard and acrolein which in turn alkylate DNA and proteins, respectively [1]. It is widely used in the treatment of chronic lymphocytic leukemia, lymphomas, and soft tissue and osteogenic sarcomas. [2]
Cyclophosphamide was shown to induce apoptosis in wt 9L gliosarcoma cells that did not express Bcl-2. Bcl-2 diminishes cyclophosphamide's cytotoxic activity, but not cytostatic activity. [1]
Technical information:
| Chemical Formula: | C7H15Cl2N2O2P.H2O | |
| CAS #: | 6055-19-2 | |
| Molecular Weight: | 261.09 | |
| Purity: | > 99% | |
| Appearance: | White Crystalline | |
| Chemical Name: | (RS)-N,N-bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide | |
| Solubility: | Up to 100 mM in DMSO | |
| Synonyms: | Cyclophosphamide, Endoxan, Cytoxan, Neosar, Procytox, Revimmune, Cytophosphane |
Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.
Reference:
| 1. | Schwartz et al., Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol. Pharmcol. 2001, 60(6), 1268-1279. Pubmed ID: 11723234 |
| 2. | Cyclophosphamide IARC monograph |
Other Information:
Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.
