Loading... Please wait...

Our Newsletter


Staurosporine | pan-kinase inhibitor

  • Staurosporine.jpg
  • Staurosporine, 400x400px, png
Price:
$159.00
Catalog #:
C7828-2s
Quantity:


Product Description

Staurosporine is a natural product isolated from the bacterium Streptomyces staurosporeus. It is a very potent and broad spectrum protein kinase inhibitor through the prevention of ATP binding to the kinase. It inhibits protein kinase C (IC50=0.7nM), CDK1/cyclin B (IC50=5nM), CDK2/cyclin A (IC50=7nM), CDK4/cyclin D (IC50=3-10nM), CDK5/p25 (IC50=4nM), GSK-3β (IC50=15nM), Pim-1 kinase (IC50=10nM). It induces apoptosis in human neuroblastoma cell lines and chick embryonic neurons. Due to its broad and potent kinase inhibition activities, staurospoine is routinely used as cytotoxic, anti-proliferative reference compound.


Technical information:

Chemical Formula:   C28H26N4O3
CAS #:   62996-74-1
Molecular Weight:   466.53
Purity:   >98%
Appearance:   White solid
Chemical Name:   (5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-17-oxa-4b,9a,15-triaza-5,9-methanodibenzo[b,h]cyclonona[jkl]cyclopenta[e]-as-indacen-14(5H)-one
Solubility:   Up to 100 mM in DMSO

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Tamaoki et al. Staurosporine, a potent inhibitor of phospholipid/Ca2+ dependent protein kinase. Biochem Biophys Res Commun. (1986) 135 397.
2. Boix, J., et al. Characterization of the cell death process induced by staurosporine in human neuroblastoma cell lines. Neuropharmacology (1997) 36: 811-821
3. Karaman MW, et al. A quantitative analysis of kinase inhibitor selectivity. Nat. Biotechnol. (2008) 26 (1): 127–132

Other Information:

Product Specification (pdf)
MSDS (pdf)

Write your own product review

Product Reviews

This product hasn't received any reviews yet. Be the first to review this product!

Add to Wish List

Click the button below to add the Staurosporine | pan-kinase inhibitor to your wish list.

You Recently Viewed...