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T-705 (Favipiravir) | Anti-influenza compound

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Price:
$129.00
Catalog #:
C8705-5
Quantity:


Product Description

T-705 (Favipiravir) is an antiviral pyrazinecarboxamide-based, inhibitor of of the influenza virus with an EC90 of 1.3 to 7.7 uM (influenza A, H5N1). EC90 ranges for other influenza A subtypes are 0.19-1.3 uM, 0.063-1.9 uM, and 0.5-3.1 uM for H1N1, H2N2, and H3N2, respectively. T-705 also exhibits activity against type B and C viruses, with EC90s of 0.25-0.57 uM and 0.19-0.36 uM, respectively. (1) Additionally, T-705 has broad activity against arenavirus, bunyavirus, foot-and-mouth disease virus, and West Nile virus with EC50s ranging from 5 to 300 uM. (1)

Studies show that T-705 ribofuranosyl triphosphate is the active form of T-705 and acts like purines or purine nucleosides in cells and does not inhibit DNA synthesis. (2)


Technical information:

Chemical Formula:   C5H4FN3O2
CAS #:   259793-96-9
Molecular Weight:   157.1
Purity:   > 98%
Appearance:   off white
Chemical Name:   6-fluoro-3-hydroxy-2-pyrazinecarboxamide
Solubility:   Up to 100 mM in DMSO
Synonyms:   T-705, T705, Favipiravir

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder at 4oC desiccated, or store DMSO solution at -20oC.


Reference:

1. Furuta et al., T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res. 2009, 82, 95-102. Pubmed ID: 19428599
2. Kiso et al., T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. 2010, 107(2), 882-887. Pubmed ID: 20080770

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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