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Fulvestrant (ICI-182780)

  • Fulvestrant 200x200
  • Fulvestrant 600x600
Price:
$49.00
Catalog #:
C4218-10
Quantity:


Product Description

Fulvestrant (ICI-182780) is an estrogen receptor (ER) antagonist with an IC50 of 9.4 nM in a cell-free assay. It shows potent inhibitory effect in the growth of MCF-7 human breast cancer cells, with an IC50 of 0.29 nM. [1] Unlike tamoxifen, Fulvestrant (ICI-182780) is devoid of agonist activity and serves as a “pure” antioestrogen. [1]

Binding of Fulvestrant to the ER induces a rapid loss of ER protein from breast carcinoma cells. [2]
Fulvestrant (ICI-182780) is approved by FDA for the treatment of ER?-positive metastatic breast cancer in postmenopausal women with disease progression following anti-estrogen therapy. It has been also subjected in a Phase III clinical trial in patients with HER2 negative postmenopausal metastatic breast cancer. [3]"


Technical information:

Chemical Formula:   C32H47F5O3S
CAS #:   129453-61-8
Molecular Weight:   606.77
Purity:   > 98%
Appearance:   White
Chemical Name:   7-[9-[(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl]-(7?,17?)-estra-1,3,5(10)-triene-3,17-diol
Solubility:   Up to 100 mM in DMSO
Synonyms:   Fulvestrant, ICI-182780, ZD 9238, Faslodex

Shipping Condition: The product is shipped in a glass vial at ambient temperature.
Storage condition: For longer shelf life, store solid powder or DMSO solution at -20oC desiccated.


Reference:

1. Wakeling AE, et al. A potent specific pure antiestrogen with clinical potential. Cancer Res. 1991; 51(15):3867-73 Pubmed ID: 1855205
2. Wakeling AE. Similarities and distinctions in the mode of action of different classes of antioestrogens. Endocr Relat Cancer. 2000; 7(1):17-28 Pubmed ID: 10808193
3. Fulvestrant as Maintenance Therapy After First-line Chemotherapy in HER2 - Postmenopausal MBC Patients (FUMANCE). clinicaltrials/NCT02383030 

Other Information:

Product Specification (pdf)
MSDS (pdf)
Certificate of Analysis is available upon request.

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